Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure
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چکیده
منابع مشابه
Noise-induced hyperactivity in the inferior colliculus: its relationship with hyperactivity in the dorsal cochlear nucleus.
Intense noise exposure causes hyperactivity to develop in the mammalian dorsal cochlear nucleus (DCN) and inferior colliculus (IC). It has not yet been established whether the IC hyperactivity is driven by hyperactivity from extrinsic sources that include the DCN or instead is maintained independently of this input. We have investigated the extent to which IC hyperactivity is dependent on input...
متن کاملChanges in spontaneous neural activity in the dorsal cochlear nucleus following exposure to intense sound: relation to threshold shift.
Previous studies have shown that the dorsal cochlear nucleus exhibits increased spontaneous activity after exposure to intense sound. Such increases were apparent 1-2 months after the exposure and were generally proportional to the shift in response thresholds induced by the same exposure. The purpose of the present study was to determine whether this sound-induced increase in spontaneous activ...
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Local circuit interactions between the dorsal and ventral divisions of the cochlear nucleus are known to influence the evoked responses of the resident neurons to sound. In the present study, we examined the projections of neurons in the ventral cochlear nucleus to the dorsal cochlear nucleus by using retrograde transport of biotinylated dextran amine injected into restricted but different regi...
متن کاملTemporal representation of the delay of iterated rippled noise in the dorsal cochlear nucleus.
It has been suggested that the dorsal cochlear nucleus (DCN) is involved in the temporal representation of both envelope periodicity and pitch. This hypothesis is tested using iterated rippled noise (IRN), which is generated by a cascade of delay and add [IRN(+)] or delay and subtract [IRN(-)] operations. The autocorrelation functions (ACFs) of the waveform and the envelope of IRN(+) have a fir...
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What are the mechanisms that enhance the response to behaviorally relevant external stimuli? In this issue of Neuron, Kuo and Trussell show that in the dorsal cochlear nucleus, noradrenaline functions to simultaneously reduce spontaneous inhibitory inputs while increasing evoked inhibition.
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2019
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2019.4316